Article
Entropy and surface engineering in protein crystallization.
Acta crystallographica. Section D, Biological crystallography - 1 Jan 2006
Derewenda Zygmunt S, Vekilov Peter G
Abstract excerpt
Protein crystallization remains a key limiting step in the characterization of the atomic structures of proteins and their complexes by X-ray diffraction methods. Current data indicate that standard screening procedures applied to soluble well folded prokaryotic proteins yield X-ray diffraction crystals with an approximately 20% success rate and for eukaryotic proteins this figure may be significantly lower....
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