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Cag3 Is a Novel Essential Component of the<i>Helicobacter pylori</i>Cag Type IV Secretion System Outer Membrane Subcomplex

3 Oct 2009

Abstract excerpt

Helicobacter pylori strains harboring the cag pathogenicity island (PAI) have been associated with more severe gastric disease in infected humans. The cag PAI encodes a type IV secretion (T4S) system required for CagA translocation into host cells as well as induction of proinflammatory cytokines, such as interleukin-8 (IL-8). cag PAI genes sharing sequence similarity with T4S components from other bacteria are...

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PMID: 19801411
DOI: 10.1128/jb.00946-09

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