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Article

A new type of non-Ca2+-buffering Apo(a)-based fluorescent indicator for intraluminal Ca2+ in the endoplasmic reticulum.

The Journal of biological chemistry - 24 Feb 2006

Osibow Karin, Malli Roland, Kostner Gerhard M, Graier Wolfgang F

Abstract excerpt

Genetically encoded Ca2+ indicators are outstanding tools for the assessment of intracellular/organelle Ca2+ dynamics. Basically, most indicators contain the Ca2+-binding site of a (mutated) cytosolic protein that interacts with its natural (mutated) interaction partner upon binding of Ca2+. Consequently, a change in the structure of the sensor occurs that, in turn, alters the fluorescent properties of the...

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PMID: 16368693
DOI: 10.1074/jbc.M508583200
PMCID: PMC4845882

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