Article
Associations between ERalpha, ERbeta, and AR genotypes and colon and rectal cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Dec 2005
Slattery Martha L, Sweeney Carol, Murtaugh Maureen, Ma Khe Ni, Wolff Roger K, Potter John D, Caan Bette J, Samowitz Wade
Abstract excerpt
Estrogen and androgens are thought to be involved in the etiology of colorectal cancer. We evaluate genetic variants of the estrogen receptor genes (ERalpha and ERbeta) and the androgen receptor gene (AR). We use data from two large case-control studies of colon (n = 1,580 cases and 1,968 controls) and rectal (n = 797 cases and 1,016 controls) cancer. We evaluated the 351A >G XbaI polymorphism of ERalpha, the...
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