Article
Repeat polymorphisms in ESR2 and AR and colorectal cancer risk and prognosis: results from a German population-based case-control study.
BMC cancer - 7 Nov 2014
Rudolph Anja, Shi Hong, Försti Asta, Hoffmeister Michael, Sainz Juan, Jansen Lina, Hemminki Kari, Brenner Hermann, Chang-Claude Jenny
Abstract excerpt
BACKGROUND: Evidence has accumulated which suggests that sex steroids influence colorectal cancer development and progression. We therefore assessed the association of repeat polymorphisms in the estrogen receptor β gene (ESR2) and the androgen receptor gene (AR) with colorectal cancer risk and prognosis. METHODS: The ESR2 CA and AR CAG repeat polymorphisms were genotyped in 1798 cases (746 female, 1052 male) and...
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