Article
Conformation preserved in a weak-to-strong or strong-to-weak [PSI+] conversion during transmission to Sup35 prion variants.
Biochimie - 1 May 2006
Crist Colin G, Kurahashi Hiroshi, Nakayashiki Toru, Nakamura Yoshikazu
Abstract excerpt
The cytoplasmic [PSI(+)] element of budding yeast represents the prion conformation of translation release factor Sup35. Much interest lies in understanding how prions are able to generate variation in isogenic strains. Recent observations suggest that a single prion domain, PrD, is able to adopt several conformations that account for prion strains. We report novel PrD variants of Sup35 that convert weak [PSI(+)]...
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