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Article

Identification of otubain 1 as a novel substrate for the <i>Yersinia</i> protein kinase using chemical genetics and mass spectrometry

9 Dec 2005

Abstract excerpt

Yersinia encodes a protein kinase, YpkA, which disrupts the actin cytoskeleton. Using an approach termed chemical genetics, we identified a 36-kDa substrate for YpkA in both J774 lysates and bovine brain cytosol. Mass spectrometry analysis identified this substrate as FLJ20113, an open reading frame that corresponds to otubain 1, a deubiquitinating enzyme implicated in immune cell clonal anergy. We demonstrate...

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PMID: 16364312
DOI: 10.1016/j.febslet.2005.11.071

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