Article
Quantitation of heteroplasmy of mtDNA sequence variants identified in a population of AD patients and controls by array-based resequencing.
Mitochondrion - 1 Aug 2006
Coon Keith D, Valla Jon, Szelinger Szabolics, Schneider Lonnie E, Niedzielko Tracy L, Brown Kevin M, Pearson John V, Halperin Rebecca, Dunckley Travis, Papassotiropoulos Andreas, Caselli Richard J, Reiman Eric M, Stephan Dietrich A
Abstract excerpt
The role of mitochondrial dysfunction in the pathogenesis of Alzheimer's disease (AD) has been well documented. Though evidence for the role of mitochondria in AD seems incontrovertible, the impact of mitochondrial DNA (mtDNA) mutations in AD etiology remains controversial. Though mutations in mitochondrially encoded genes have repeatedly been implicated in the pathogenesis of AD, many of these studies have been...
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