The MT-CO1 V83I Polymorphism is a Risk Factor for Primary Open-Angle Glaucoma in African American Men.

doi:10.1167/iovs.17-23277

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

The MT-CO1 V83I Polymorphism is a Risk Factor for Primary Open-Angle Glaucoma in African American Men.

Investigative ophthalmology & visual science - 1 Apr 2018

Collins David W, Gudiseva Harini V, Chavali Venkata R M, Trachtman Benjamin, Ramakrishnan Meera, Merritt William T, Pistilli Maxwell, Rossi Rebecca A, Blachon Stephanie, Sankar Prithvi S, Miller-Ellis Eydie, Lehman Amanda, Addis Victoria, O'Brien Joan M

Abstract excerpt

Purpose: We investigate the function of the V83I polymorphism (m.6150G>A, rs879053914) in the mitochondrial cytochrome c oxidase subunit 1 (MT-CO1) gene and its role in African American (AA) primary open-angle glaucoma (POAG). Methods: This study used Sanger sequencing (1339 cases, 850 controls), phenotypic characterization of Primary Open-Angle African American Glaucoma Genetics study (POAAGG) cases, a masked...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Amyloid beta-Peptides

Share to Autophagy-Related Proteins

Share to Black or African American

Share to Electron Transport Complex IV

Share to Enzyme-Linked Immunosorbent Assay

Share to Glaucoma, Open-Angle

Share to Sex Characteristics

Source

Open in PubMed Open full text

Identifiers

PMID: 29610859
DOI: 10.1167/iovs.17-23277
PMCID: PMC5886029

Genes

UBQLN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The MT-CO1 V83I Polymorphism is a Risk Factor for Primary Open-Angle Glaucoma in African American Men.PMID 29610859Read ↗

Mitochondrial sequence variation in African-American primary open-angle glaucoma patients.Semantic proximity Read ↗

Identification of a novel MYOC variant in a Hispanic family with early-onset primary open-angle glaucoma with elevated intraocular pressure.Semantic proximity Read ↗

Association of genetic variants in the TMCO1 gene with clinical parameters related to glaucoma and characterization of the protein in the eye.Semantic proximity Read ↗

Mutations in the ABCA3 gene are associated with cataract-microcornea syndrome.Semantic proximity Read ↗

MYOC mutations in black south african patients with primary open-angle glaucoma: genetic testing and cascade screening.Semantic proximity Read ↗

Abrogation of HMX1 function causes rare oculoauricular syndrome associated with congenital cataract, anterior segment dysgenesis, and retinal dystrophy.Semantic proximity Read ↗

A Mitochondrial Genome-Wide Association Study of Cataract in a Latino Population.Semantic proximity Read ↗

Mutations in mitochondrial‐encoded cytochrome <b><i>c</i></b> oxidase subunits I, II, and III genes detected in Alzheimer's disease using single‐strand conformation polymorphismSemantic proximity Read ↗

A functional variant in the CFI gene confers a high risk of age-related macular degeneration.Semantic proximity Read ↗

A novel MT-CO1 m.6498C>A variation associated with the m.7444G>A mutation in the mitochondrial COI/tRNA(Ser(UCN)) genes in a patient with hearing impairment, diabetes and congenital visual loss.Semantic proximity Read ↗

OPA1 mutations and mitochondrial DNA haplotypes in autosomal dominant optic atrophy.Semantic proximity Read ↗

Abnormal creatine transport of mutations in monocarboxylate transporter 12 (MCT12) found in patients with age-related cataract can be partially rescued by exogenous chaperone CD147.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.