Article
Genomic profiling associated with recurrence in patients with rectal cancer treated with chemoradiation.
Pharmacogenomics - 1 Jan 2006
Gordon Michael A, Gil Ji, Lu Bo, Zhang Wu, Yang Dongyun, Yun Jim, Schneider Sylke, Groshen Susan, Iqbal Syma, Press Oliver A, Rhodes Katrin, Lenz Heinz-Josef
Abstract excerpt
PURPOSE: Stage II and III adenocarcinoma of the rectum has an overall 5-year survival rate of approximately 50%, and tumor recurrence remains a major problem despite an improvement in local control through chemotherapy and radiation. The efficacy of chemoradiation therapy may be significantly compromised as a result of interindividual variations in clinical response and host toxicity. Therefore, it is imperative...
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