Article
Validation study of a quantitative multigene reverse transcriptase-polymerase chain reaction assay for assessment of recurrence risk in patients with stage II colon cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Dec 2011
Gray Richard G, Quirke Philip, Handley Kelly, Lopatin Margarita, Magill Laura, Baehner Frederick L, Beaumont Claire, Clark-Langone Kim M, Yoshizawa Carl N, Lee Mark, Watson Drew, Shak Steven, Kerr David J
Abstract excerpt
PURPOSE: We developed quantitative gene expression assays to assess recurrence risk and benefits from chemotherapy in patients with stage II colon cancer. PATIENTS AND METHODS: We sought validation by using RNA extracted from fixed paraffin-embedded primary colon tumor blocks from 1,436 patients with stage II colon cancer in the QUASAR (Quick and Simple and Reliable) study of adjuvant fluoropyrimidine...
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