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Two thiosemicarbazones derived from 1-indanone as potent non-nucleoside inhibitors of bovine viral diarrhea virus of different genotypes and biotypes.

Virology - 1 Oct 2024

Fabiani Matías, Castro Eliana F, Battini Leandro, Rosas Rocío A, Gärtner Benjamin, Bollini Mariela, Cavallaro Lucía V

Abstract excerpt

Bovine viral diarrhea virus (BVDV) is a widespread pathogen of cattle and other mammals that causes major economic losses in the livestock industry. N4-TSC and 6NO2-TSC are two thiosemicarbazones derived from 1-indanone that exhibit anti-BVDV activity in vitro. These compounds selectively inhibit BVDV and are effective against both cytopathic and non-cytopathic BVDV-1 and BVDV-2 strains. We confirmed that N4-TSC...

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Antiviral Agents
Diarrhea Virus 1, Bovine Viral
Diarrhea Viruses, Bovine Viral
Drug Resistance, Viral
Indans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA-Dependent RNA Polymerase

Virus Replication

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Identifiers

PMID: 39089051
DOI: 10.1016/j.virol.2024.110189

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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