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The hamartoma-adenoma-carcinoma sequence

1 May 1999

Abstract excerpt

Carcinomas develop, although at low frequency, in hamartomatous polyps in the Peutz-Jeghers' syndrome. With the identification of at least one of the genes involved (LKB1/STK11), attempts can be made to unravel the molecular events responsible for this hamartoma-adenoma-carcinoma sequence. Recent data indicate that this sequence is real, that the molecular pathways involved are different from those in other...

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PMID: 10398131
DOI: 10.1002/(sici)1096-9896(199905)188:1<1::aid-path327>3.0.co;2-j

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