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Article

A new SNP in a negative regulatory region of the CYP19A1 gene is associated with lumbar spine BMD in postmenopausal women.

Bone - 1 May 2006

Enjuanes Anna, Garcia-Giralt Natalia, Supervía August, Nogués Xavier, Ruiz-Gaspà Silvia, Bustamante Mariona, Mellibovsky Leonardo, Grinberg Daniel, Balcells Susana, Díez-Pérez Adolfo

Abstract excerpt

Osteoporosis is a common disease of bone possessing a strong genetic component. Cytochrome P450 aromatase, which is encoded by the CYP19A1 gene, converts androgens to estradiol. Considerable evidence suggests that extragonadal estrogens play an important role in determining bone mineral density (BMD) in postmenopausal women, and, among them, those synthesized in bone cells may also be important for the...

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PMID: 16344016
DOI: 10.1016/j.bone.2005.10.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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