Article
Genetic characterization and protective immunity of cold-adapted attenuated avian H9N2 influenza vaccine.
Vaccine - 2 Dec 2008
Lee Joo Sub, Kim Hyun Soo, Seo Sang Heui
Abstract excerpt
H9N2 influenza viruses are endemic in many Asian countries including China and Korea, and cause a considerable economic loss to chicken industry by reduction in egg production and about 30% mortality. Here we developed live cold-adapted attenuated H9N2 influenza vaccine by adaptation of viruses in hen's eggs at 25 degrees C. Genetic analysis shows that the cold-adapted H9N2 (A/Chicken/Korea/S1/03) viruses contain...
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