Article
Endophenotypes successfully lead to gene identification: results from the collaborative study on the genetics of alcoholism.
Behavior genetics - 1 Jan 2006
Dick Danielle M, Jones Kevin, Saccone Nancy, Hinrichs Anthony, Wang Jen C, Goate Alison, Bierut Laura, Almasy Laura, Schuckit Marc, Hesselbrock Victor, Tischfield Jay, Foroud Tatiana, Edenberg Howard, Porjesz Bernice, Begleiter Henri
Abstract excerpt
The use of endophenotypes has been proposed as a strategy to aid gene identification efforts for complex phenotypes [Gottesman, I. I., and Shields J. (1972). Schizophrenia and Genetics: A Twin Study Vantage Point. London: Academic]. As part of the Collaborative Study of the Genetics of Alcoholism (COGA) project, we have analyzed electrophysiological endophenotypes, in addition to clinical diagnoses, as part of...
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