Article
Domain requirements of the JIL-1 tandem kinase for histone H3 serine 10 phosphorylation and chromatin remodeling in vivo.
The Journal of biological chemistry - 5 Jul 2013
Li Yeran, Cai Weili, Wang Chao, Yao Changfu, Bao Xiaomin, Deng Huai, Girton Jack, Johansen Jørgen, Johansen Kristen M
Abstract excerpt
The JIL-1 kinase localizes to Drosophila polytene chromosome interbands and phosphorylates histone H3 at interphase, counteracting histone H3 lysine 9 dimethylation and gene silencing. JIL-1 can be divided into four main domains, including an NH2-terminal domain, two separate kinase domains, and a COOH-terminal domain. In this study, we characterize the domain requirements of the JIL-1 kinase for histone H3...
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