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Article

Abl kinase regulation by BRAF/ERK and cooperation with Akt in melanoma.

Oncogene - 10 Aug 2017

Jain A, Tripathi R, Turpin C P, Wang C, Plattner R

Abstract excerpt

The melanoma incidence continues to increase, and the disease remains incurable for many due to its metastatic nature and high rate of therapeutic resistance. In particular, melanomas harboring BRAFV600E and PTEN mutations often are resistant to current therapies, including BRAF inhibitors (BRAFi) and immune checkpoint inhibitors. Abl kinases (Abl/Arg) are activated in melanomas and drive progression; however,...

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Source

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Identifiers

PMID: 28368422
DOI: 10.1038/onc.2017.76
PMCID: PMC5552414

Genes

BRAF
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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