Article
Dok1 expression and mutation in Burkitt's lymphoma cell lines.
Cancer letters - 8 Jan 2007
Lee Sanghoon, Huang Hervé, Niu Yamei, Tommasino Massimo, Lenoir Gilbert, Sylla Bakary S
Abstract excerpt
Dok1 is an adaptor tyrosine kinase substrate with tumor-suppressive activity. The gene encoding Dok1 maps to human chromosome 2p13, which is frequently rearranged in human tumors. We have previously reported a frameshift mutation of this gene and the down-regulation of its expression in chronic lymphocytic leukemia. In this study, we have determined the expression levels of Dok1 in Burkitt's lymphoma (BL) cell...
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