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Article

Caenorhabditis elegans gcs-1 confers resistance to arsenic-induced oxidative stress.

Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine - 1 Oct 2005

Liao Vivian Hsiu-Chuan, Yu Chan-Wei

Abstract excerpt

Gamma-glutamylcysteine synthetase (gamma-GCS) catalyzes the first, rate-limiting step in the biosynthesis of glutathione (GSH). To evaluate the protective role of cellular GSH against arsenic-induced oxidative stress in Caenorhabditis elegans (C. elegans), we examined the effect of the C. elegans ortholog of GCS(h), gcs-1, in response to inorganic arsenic exposure. We have evaluated the responses of wild-type and...

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Identifiers

PMID: 16333752
DOI: 10.1007/s10534-005-2996-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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