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Article

Tgfbr2 disruption in postnatal smooth muscle impairs aortic wall homeostasis.

The Journal of clinical investigation - 1 Feb 2014

Li Wei, Li Qingle, Jiao Yang, Qin Lingfeng, Ali Rahmat, Zhou Jing, Ferruzzi Jacopo, Kim Richard W, Geirsson Arnar, Dietz Harry C, Offermanns Stefan, Humphrey Jay D, Tellides George

Abstract excerpt

TGF-β is essential for vascular development; however, excess TGF-β signaling promotes thoracic aortic aneurysm and dissection in multiple disorders, including Marfan syndrome. Since the pathology of TGF-β overactivity manifests primarily within the arterial media, it is widely assumed that suppression of TGF-β signaling in vascular smooth muscle cells will ameliorate aortic disease. We tested this hypothesis by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Muscle, Smooth, Vascular

Share to Receptor, Transforming Growth Factor-beta Type II

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Source

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Identifiers

PMID: 24401272
DOI: 10.1172/JCI69942
PMCID: PMC3904608

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