Article
A systematic search for a bipolar predisposing locus on chromosome 5.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jun 1992
Detera-Wadleigh S D, Berrettini W H, Goldin L R, Martinez M, Hsieh W T, Hoehe M R, Encio I J, Coffman D, Rollins D Y, Muniec D
Abstract excerpt
Chromosome 5 markers spanning the pter to the qter were used to examine linkage to bipolar illness in 14 pedigrees. Twenty-four loci were examined in 237 individuals, of whom 69 were either bipolars or schizoaffectives. Marker genotypes were determined for each individual and lod scores were calculated under a dominant disease model with a maximum penetrance of 85%, a disease gene frequency of 0.015, a variable...
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