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Article

A novel folding intermediate state for apolipoprotein A-I: role of the amino and carboxy termini.

Biophysical journal - 15 Feb 2006

Gross Eitan, Peng Dao-Quan, Hazen Stanley L, Smith Jonathan D

Abstract excerpt

Intramolecular interactions between the amino and carboxy termini of apolipoprotein A-I (apoAI) are believed to stabilize the helix bundle conformation of the protein. During lipid assembly the protein undergoes conformational changes that result in an exposure of the carboxy terminus and its insertion into the lipid phase. To determine the role of the two termini in the energetics of unfolding, we studied the...

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Identifiers

PMID: 16326917
DOI: 10.1529/biophysj.105.075069
PMCID: PMC1367287

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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