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Article

Lipid-binding studies of human apolipoprotein A-I and its terminally truncated mutants.

Biochemistry - 18 Nov 2003

Fang Yiling, Gursky Olga, Atkinson David

Abstract excerpt

Apolipoprotein A-I (apoA-I, 243 amino acids) is the major protein of high-density lipoproteins (HDL) that plays an important structural and functional role in lipid transport and metabolism. The central region of apoA-I (residues 60-183) is predicted to contain exclusively amphipathic alpha-helices formed from tandem 22-mer sequence repeats. To analyze the lipid-binding properties of this core domain, four...

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PMID: 14609337
DOI: 10.1021/bi0354031

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