Article
The C-terminal domain of apolipoprotein A-I contains a lipid-sensitive conformational trigger.
Nature structural biology - 1 Jun 2003
Oda Michael N, Forte Trudy M, Ryan Robert O, Voss John C
Abstract excerpt
Exchangeable apolipoproteins can convert between lipid-free and lipid-associated states. The C-terminal domain of human apolipoprotein A-I (apoA-I) plays a role in both lipid binding and self-association. Site-directed spin-label electron paramagnetic resonance spectroscopy was used to examine the structure of the apoA-I C terminus in lipid-free and lipid-associated states. Nitroxide spin-labels positioned at...
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