Article

Obacunone mitigates smoke/LPS–driven oxidative and inflammatory lung injury in models of COPD exacerbation via NRF2 activation

2026-06-16

Abstract excerpt

<b>Background:</b> Chronic obstructive pulmonary disease (COPD) is characterized by persistent oxidative stress and neutrophilic inflammation, which intensify during acute exacerbations. These processes contribute to epithelial damage, impaired redox balance, and heightened cytokine and protease activity. Pharmacological activation of the transcription factor nuclear factor erythroid 2–related factor 2 (NRF2) repr...

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Literature Corpus work: fc4da9b3-07ad-5eb5-9b88-ad73831ceca7
DOI: 10.22541/authorea.15004834/v1

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