Article
Polymorphisms of the DNA repair genes XPD (Lys751Gln) and XRCC1 (Arg399Gln and Arg194Trp): relationship to breast cancer risk and familial predisposition to breast cancer.
Breast cancer research and treatment - 1 Jan 2006
Brewster A M, Jorgensen T J, Ruczinski I, Huang H Y, Hoffman S, Thuita L, Newschaffer C, Lunn R M, Bell D, Helzlsouer K J
Abstract excerpt
Family history is a risk factor for breast cancer and could be due to shared environmental factors or polymorphisms of cancer susceptibility genes. Deficient function of DNA repair enzymes may partially explain familial risk as polymorphisms of DNA repair genes have been associated, although inconsistently, with breast cancer. This population based case-control study examined the association between polymorphisms...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.