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Article

Reciprocal gene replacements reveal unique functions for Phox2 genes during neural differentiation.

The EMBO journal - 21 Dec 2005

Coppola Eva, Pattyn Alexandre, Guthrie Sarah C, Goridis Christo, Studer Michèle

Abstract excerpt

The paralogous paired-like homeobox genes Phox2a and Phox2b are involved in the development of specific neural subtypes in the central and peripheral nervous systems. The different phenotypes of Phox2 knockout mutants, together with their asynchronous onset of expression, prompted us to generate two knock-in mutant mice, in which Phox2a is replaced by the Phox2b coding sequence, and vice versa. Our results...

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Identifiers

PMID: 16319924
DOI: 10.1038/sj.emboj.7600897
PMCID: PMC1356338

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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