Article
Increased number of aldosterone-sensitive NTS neurons in Dahl salt-sensitive rats.
Brain research - 14 Dec 2005
Geerling Joel C, Sequeira Sunitha M, Loewy Arthur D
Abstract excerpt
Dahl salt-sensitive rats develop severe hypertension during a high-sodium diet, but the basis of their salt-sensitive phenotype is not completely understood. A subset of neurons in the nucleus tractus solitarius (NTS) are uniquely sensitive to the adrenal steroid hormone aldosterone, which is critically involved in sodium homeostasis, due to their expression of the enzyme 11-beta-hydroxysteroid dehydrogenase type...
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