Prion disease genetics.

doi:10.1038/sj.ejhg.5201544

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Article

Prion disease genetics.

European journal of human genetics : EJHG - 1 Mar 2006

Mead Simon

Abstract excerpt

Prion diseases have stimulated intense scientific scrutiny since it was proposed that the infectious agent was devoid of nucleic acid. Despite this finding, genetics has played a key role in understanding the pathobiology and clinical aspects of prion disease through the effects of a series of polymorphisms and mutations in the prion protein gene (PRNP). The advent of variant Creutzfeldt-Jakob disease has...

Topics

Adult
Age Factors
Aged
Aged, 80 and over
Animals
Cerebellum
Creutzfeldt-Jakob Syndrome
Genetic Predisposition to Disease
Genetic Variation
Genotype
Humans
Male
Mice
Middle Aged
Models, Genetic
Mutation
Nucleic Acids
Phenotype

Source

Open in PubMed

Identifiers

PMID: 16391566
DOI: 10.1038/sj.ejhg.5201544

Genes

PRNP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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