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Article

Common conformational changes induced in type 2 picornavirus IRESs by cognate trans-acting factors.

Nucleic acids research - 1 Jun 2011

Yu Yingpu, Abaeva Irina S, Marintchev Assen, Pestova Tatyana V, Hellen Christopher U T

Abstract excerpt

Type 2 internal ribosomal entry sites (IRESs) of encephalomyocarditis virus (EMCV), foot-and-mouth disease virus (FMDV) and other picornaviruses comprise five major domains H-L. Initiation of translation on these IRESs begins with specific binding of the central domain of initiation factor, eIF4G to the J-K domains, which is stimulated by eIF4A. eIF4G/eIF4A then restructure the region of ribosomal attachment on...

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PMID: 21306989
DOI: 10.1093/nar/gkr045
PMCID: PMC3113573

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