Article
Joint effect of HSD3B1 and HSD3B2 genes is associated with hereditary and sporadic prostate cancer susceptibility.
Cancer research - 15 Mar 2002
Chang Bao-li, Zheng Siqun L, Hawkins Gregory A, Isaacs Sarah D, Wiley Kathy E, Turner Aubrey, Carpten John D, Bleecker Eugene R, Walsh Patrick C, Trent Jeffrey M, Meyers Deborah A, Isaacs William B, Xu Jianfeng
Abstract excerpt
3beta-hydroxysteroid dehydrogenases (HSD3Bs), encoded by the HSD3B gene family at 1p13, have long been hypothesized to have a major role in prostate cancer susceptibility. The recent reports of a prostate cancer linkage at 1p13 provided additional evidence that HSD3B genes may be prostate cancer susceptibility genes. To evaluate the possible role of HSD3B genes in prostate cancer, we screened a panel of DNA...
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