Article
Association of alcohol dehydrogenase 2*1 allele with liver damage and insulin concentration in the Japanese.
Journal of human genetics - 1 Jan 2006
Suzuki Yoshihiko, Ando Fujiko, Ohsawa Ikuroh, Shimokata Hiroshi, Ohta Shigeo
Abstract excerpt
The Japanese have a polymorphism in the alcohol dehydrogenase 2 gene (ADH2). The alleles of ADH2 (ADH2*1 and ADH2*2) encode more active and less active forms for ethanol metabolism, respectively. We examined whether liver damage and the insulin-glucose axis vary according to ADH2 genotype in the Japanese. The 2,232 subjects (1,126 men and 1,106 women) were recruited from a population-based prospective cohort...
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