Computational studies on the resistance of penicillin-binding protein 2B (PBP2B) of wild-type and mutant strains of Streptococcus pneumoniae against β-lactam antibiotics.

Abstract excerpt

Mutations within transpeptidase domain of penicillin-binding protein 2B of the strains of Streptococcus pneumoniae leads to resistance against β-lactam antibiotics. To uncover the important residues responsible for sensitivity and resistance, the recently determined three dimensional structures of penicillin-binding protein 2B of both wild-type R6 (sensitive) and mutant 5204 (resistant) strains along with the...

Topics

• Amino Acid Sequence
• Aminoacyltransferases
• Anti-Bacterial Agents
• Binding Sites
• Drug Resistance, Bacterial
• Molecular Docking Simulation
• Molecular Sequence Data
• Mutation
• Penicillin-Binding Proteins
• Protein Structure, Tertiary