Article

Genetic instability and darwinian selection in tumours

1999-12-01

Abstract excerpt

Genetic instability has long been hypothesized to be a cardinal feature of cancer. Recent work has strengthened the proposal that mutational alterations conferring instability occur early during tumour formation. The ensuing genetic instability drives tumour progression by generating mutations in oncogenes and tumour-suppressor genes. These mutant genes provide cancer cells with a selective growth advantage, there...

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Literature Corpus work: 9c6cfe42-8581-5098-b531-a73fbd2a13eb
DOI: 10.1016/s0168-9525(99)01874-0

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