Article
Frequency of hepatitis B virus 'a' determinant variants in unselected Spanish chronic carriers.
Journal of medical virology - 1 Jan 2006
Avellón Ana, Echevarria José M
Abstract excerpt
The prevalence in the population of hepatitis B virus (HBV) surface antigen (HBsAg) variants that may impair diagnosis, or allow the virus to escape vaccine-induced immunity or passive immunoglobulin therapy is unknown. A genome fragment encoding HBsAg amino acids 112-212 was amplified and sequenced from the sera of 272 unselected DNA-positive, HBV-chronic carriers from Spain. The genotype and the HBsAg subtype...
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