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Investigating beta-hydroxyenduracididine formation in the biosynthesis of the mannopeptimycins.

Chemistry & biology - 1 Nov 2005

Haltli Brad, Tan Ying, Magarvey Nathan A, Wagenaar Melissa, Yin Xihou, Greenstein Michael, Hucul John A, Zabriskie T Mark

Abstract excerpt

The mannopeptimycins (MPPs) are potent glycopeptide antibiotics that contain both D and L forms of the unique, arginine-derived amino acid beta-hydroxyenduracididine (betahEnd). The product of the mppO gene in the MPP biosynthetic cluster resembles several non-heme iron, alpha-ketoglutarate-dependent oxygenases, such as VioC and clavaminate synthase. The role of MppO in betahEnd biosynthesis was confirmed through...

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Identifiers

PMID: 16298295
DOI: 10.1016/j.chembiol.2005.09.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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