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Article

Temperature sensitive secretion of mutant myocilins.

Experimental eye research - 1 Jun 2006

Vollrath Douglas, Liu Yuhui

Abstract excerpt

Recent studies have demonstrated that glaucoma-causing mutant myocilin proteins are misfolded and retained in the endoplasmic reticulum of cells. We showed previously that P370L mutant myocilin is poorly secreted at 37 degrees C and prolonged expression of the protein in differentiated human trabecular meshwork cells results in abnormal morphology and cell killing. Culturing cells at a lower temperature, a...

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Source

Identifiers

PMID: 16297911
DOI: 10.1016/j.exer.2005.10.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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