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Article

A Simple Secretion Assay for Assessing New and Existing Myocilin Variants.

Current eye research - 1 Jun 2022

Nakahara Emi, Hulleman John D

Abstract excerpt

PURPOSE: A lack of sufficient functional information exists for appropriately categorizing a large number of myocilin (MYOC) variants and their involvement in primary open angle glaucoma, hindering their clinical significance classification. Most glaucoma-causing MYOC mutations result in protein non-secretion and intracellular insoluble aggregate formation in cultured cells. Herein, we generated a Gaussia...

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Identifiers

PMID: 35196929
DOI: 10.1080/02713683.2022.2047205
PMCID: PMC9743483

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