Article
Autoantigen Ro52 is an E3 ubiquitin ligase.
Biochemical and biophysical research communications - 6 Jan 2006
Wada Keiji, Kamitani Tetsu
Abstract excerpt
Anti-Ro/SSA antibodies are classic autoantibodies commonly found in patients with Sjögren's syndrome, a chronic autoimmune disease characterized by dryness of the eyes and mouth. The autoantibodies recognize a RING-finger protein, Ro52, whose function is still unknown. Since many RING-finger proteins have been identified as E3 ubiquitin ligases, this study was designed to determine whether Ro52 functions as an E3...
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