The 52 000 MW Ro/SS‐A autoantigen in Sjögren's syndrome/systemic lupus erythematosus (Ro52) is an interferon‐γ inducible tripartite motif protein associated with membrane proximal structures

Abstract excerpt

The 52 000 MW Ro/SS-A (Ro52) protein is a major target of autoantibodies in autoimmune conditions such as systemic lupus erythematosus and Sjögren's syndrome. Recent genomic and bioinformatic studies have shown that Ro52 belongs to a large family of related RING/Bbox/coiled-coil (RBCC) tripartite motif proteins sharing overall domain structure and 40-50% identity at the amino acid level. Ro52 also has a B30.2...

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