UnpEL/Usp4 is ubiquitinated by Ro52 and deubiquitinated by itself.

Abstract excerpt

The autoantigen Ro52 is an E3 ubiquitin ligase that can ubiquitinate itself (self-ubiquitination). Recently, we showed that UnpEL/Usp4 is an isopeptidase that can deconjugate ubiquitin from self-ubiquitinated Ro52. Here, we showed that UnpEL is ubiquitinated by Ro52 in cooperation with UbcH5B in vitro. We also showed that UnpEL is ubiquitinated by Ro52 in HEK293T cells. Interestingly, a catalytically inactive...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Endopeptidases
• Share to Mitogen-Activated Protein Kinase Kinases
• Share to Oncogene Proteins