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Article

Interstitial cells of Cajal do not harbor c-kit or PDGFRA gene mutations in patients with sporadic gastrointestinal stromal tumors.

Journal of gastroenterology - 1 Jan 2009

Nakajima Takahiko, Miwa Shigeharu, Ando Takayuki, Fujinami Haruka, Kajiura Shinya, Hosokawa Ayumu, Takano Yasuo, Sugiyama Toshiro

Abstract excerpt

BACKGROUND: Gastrointestinal stromal tumors (GISTs) are believed to originate from the interstitial cells of Cajal (ICCs) or from the precursors of ICCs. Most GISTs show an activating mutation in either the c-kit or platelet-derived growth factor receptor alpha (PDGFRA) gene that results in a con...

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Source

Identifiers

PMID: 19333543
DOI: 10.1007/s00535-009-0032-z

Genes

PDGFRA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19333543-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Interstitial cells of Cajal do not harbor c-kit or PDGFRA gene mutations in patients with sporadic gastrointestinal stromal tumors.PMID 19333543Read ↗

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