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Article

Detection of a new mutation in KIT exon 9 in a gastrointestinal stromal tumor.

International journal of cancer - 15 Apr 2006

Hostein Isabelle, Longy Michel, Gastaldello Bernadette, Geneste Gaëlle, Coindre Jean-Michel

Abstract excerpt

Gastrointestinal stromal tumors are mesenchymal tumors arising in the stomach and small bowel and more rarely in the rectum, esophagus, peritoneum and retroperitoneum. These tumors are characterized by KIT or PDGFRA mutations. KIT mutations are all in frame and lead to constitutive tyrosine kinase domain activation without ligand binding. Mutations concern four exons (9, 11, 13 and 17) but mainly exon 11. We...

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Source

Identifiers

PMID: 16287112
DOI: 10.1002/ijc.21607

Genes

KIT
PDGFRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Detection of a new mutation in KIT exon 9 in a gastrointestinal stromal tumor.PMID 16287112Read ↗

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Mutations in exon 11 of the c-kit gene in a myogenic tumor and a neurogenic tumor as well as in gastrointestinal stromal tumors. Utility of c-kit mutation as a prognostic biomarker for gastrointestinal mesenchymal tumor.Semantic proximity Read ↗

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