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Article

Low-density lipoprotein receptor genotype and response to pravastatin in children with familial hypercholesterolemia: substudy of an intima-media thickness trial.

Circulation - 15 Nov 2005

Koeijvoets Kristel C M C, Rodenburg Jessica, Hutten Barbara A, Wiegman Albert, Kastelein John J P, Sijbrands Eric J G

Abstract excerpt

BACKGROUND: The lipid-lowering effects of statin therapy show considerable interindividual variation in patients with familial hypercholesterolemia (FH). Whether the type of LDL receptor mutation predicts the response to statin treatment is not yet established. We analyzed the relationship between LDL receptor genotype and response to pravastatin treatment in children with FH using carotid intima-media thickness...

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Identifiers

PMID: 16286607
DOI: 10.1161/CIRCULATIONAHA.105.565507

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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