Article
Low-density lipoprotein receptor genotype-dependent response to cholesterol lowering by combined pravastatin and cholestyramine in familial hypercholesterolemia.
The American journal of cardiology - 1 Jul 1998
Kajinami K, Yagi K, Higashikata T, Inazu A, Koizumi J, Mabuchi H
Abstract excerpt
We compared the effects of cholesterol-lowering therapy on 2 patient groups genetically defined as heterozygous for familial hypercholesterolemia (FH), 5 with a deletion of exon 15 (FH(Tonami-1)), and 7 with a point mutation at codon 664 (FH(Kanazawa-2)). There were significant differences in bot...
Topics
- Adult
- Aged
- Anion Exchange Resins
- Anticholesteremic Agents
- Bile
- Cholestyramine Resin
- Drug Therapy, Combination
- Female
- Genotype
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Hyperlipoproteinemia Type II
- Male
- Middle Aged
- Pravastatin
- Receptors, LDL
- Treatment Outcome