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Article

Determinants of variable response to statin treatment in patients with refractory familial hypercholesterolemia.

Arteriosclerosis, thrombosis, and vascular biology - 1 May 2001

O'Neill F H, Patel D D, Knight B L, Neuwirth C K, Bourbon M, Soutar A K, Taylor G W, Thompson G R, Naoumova R P

Abstract excerpt

Interindividual variability in low density lipoprotein (LDL) cholesterol (LDL-C) response during treatment with statins is well documented but poorly understood. To investigate potential metabolic and genetic determinants of statin responsiveness, 19 patients with refractory heterozygous familial hypercholesterolemia were sequentially treated with placebo, atorvastatin (10 mg/d), bile acid sequestrant, and the 2...

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Identifiers

PMID: 11348882
DOI: 10.1161/01.atv.21.5.832

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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