Article
Impact of low-density lipoprotein receptor mutational class on carotid atherosclerosis in patients with familial hypercholesterolemia.
Atherosclerosis - 1 Feb 2010
Junyent Mireia, Gilabert Rosa, Jarauta Estíbaliz, Núñez Isabel, Cofán Montserrat, Civeira Fernando, Pocoví Miguel, Mallén Miguel, Zambón Daniel, Almagro Fátima, Vega Juan, Tejedor Diego, Ros Emilio
Abstract excerpt
BACKGROUND AND OBJECTIVES: Defects in the low-density lipoprotein receptor (LDLR) gene cause familial hypercholesterolemia (FH), a highly atherogenic condition. The effect of different LDLR mutations on coronary heart disease (CHD) risk is insufficiently defined. We assessed carotid intima-media thickness (IMT), a surrogate marker of CHD, in relation to LDLR mutational class in FH. METHODS: In 436 Spanish FH...
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