Distribution of CCR5-Delta32, CCR2-64I, and SDF1-3'A host genetic factors in HIV-infected and uninfected individuals in Luanda, Angola.

doi:10.1186/s12981-025-00751-7

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Distribution of CCR5-Delta32, CCR2-64I, and SDF1-3'A host genetic factors in HIV-infected and uninfected individuals in Luanda, Angola.

AIDS research and therapy - 24 May 2025

Sebastião Cruz S, Pimentel Victor, Jandondo Domingos, Sebastião Joana M K, Sacomboio Euclides, Pingarilho Marta, Brito Miguel, Cassinela Edson Kuatelela, de Vasconcelos Jocelyne Neto, Abecasis Ana B, Morais Joana

Abstract excerpt

BACKGROUND: The HIV/AIDS pandemic remains a public health concern. Studies on host genetic polymorphisms that confer resistance to HIV-1 infection or delay HIV disease progression are scarce in African countries. Herein, we investigate the proportion of the mutated phenotype of the AIDS-related polymorphisms CCR5-Delta32, CCR2-64I, and SDF1-3'A in HIV-infected and uninfected individuals in Luanda, the capital of...

Topics

Humans
Receptors, CCR2
Receptors, CCR5
Chemokine CXCL12
Cross-Sectional Studies
Male
HIV Infections
Female
Adult
Angola

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Genotype

Polymorphism, Genetic

Genetic Predisposition to Disease

Young Adult

Gene Frequency

HIV-1

Adolescent

Source

Open in PubMed Open full text

Identifiers

PMID: 40413451
DOI: 10.1186/s12981-025-00751-7
PMCID: PMC12102844

Genes

CCR2
CCR5
ABO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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