Article
Isolation of constitutive variants of a subfamily 10 histidine protein kinase (SppK) from Lactobacillus using random mutagenesis.
Archives of microbiology - 1 Jan 2006
Mathiesen Geir, Axelsen Gunnhild W, Axelsson Lars, Eijsink Vincent G H
Abstract excerpt
The histidine protein kinase SppK is a peptide pheromone-activated kinase that regulates the production of the bacteriocin sakacin P in Lactobacillus sakei. SppK belongs to subfamily 10 of histidine protein kinases (HPKs), which regulate important processes in Gram-positive bacteria, including virulence, competence and bacteriocin production. To obtain insight into the functional properties of this relatively...
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